Prevalence Of Abnormal Liver Function Tests In Type 2 Diabetes Mellitus And Their Correlation With Glycemic Control And Duration Of Disease

Background: Diabetes mellitus (DM) is a syndrome of disordered metabolism with abnormally high blood glucose levels (hyperglycemia). The study was conducted to see the prevalence of abnormal liver function tests in patients with Type 2 diabetes mellitus and correlate them with glycemic control and duration of Type 2 DM so that we can detect them at early stage and prevent the long term morbidity and mortatlity. Methods: 100 patients of Type 2 diabetes mellitus attendingRajindra hospital outpatient and inpatient department were taken randomly to find out prevalence of abnormal liver abnormal liver tests. They were thoroughly investigated for liver function abnormalities. Results: The mean age of the patients was 55.15 ± 7.65 years with maximum patients in the age group of 56-60 years. Females outnumbered males in this study. The mean duration of diabetes in study group was 8.67 ± 4.07 years. Mean BMI in the study group was 28.37 ± 3.73 (kg/m2). Out of 100 patients, 50% had good glycemic control (HbA1c <7) and 50% had poor glycemic control (HbA1c ≥7). About 53% of the patients had minimum 1 abnormality of the liver function tests. Conclusion: Liver function test abnormalities showed a direct relationship with increasing duration of diabetes (p value 0.001) and increasing BMI (p value 0.031). USG abdomen showed fatty infiltration of liver in 19 patients out of which 11 had poor glycemic control as compared to rest of 8 with good glycemic control which was not statistically significant (p=0.444). These results show that poor the glycemic control, the frequency of abnormal liver function increases.

Tissue distribution and antileishmanial activity of liposomised Amphotericin-B in Balb/c mice§.

Antileishmanial activity and organ distribution of the antifungal drug Amphotericin-B in free and liposomised form have been studied in Balb/c mice infected with Leishmania donovani. Results indicate that Amphotericin-B in the liposomised form is significantly more active than the free form. This increase in the activity is perhaps related to the reduced drug toxicity rather than the altered drug distribution at the site of infection.